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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The role of promyelocytic leukemia protein in genome maintenance
 Kindlová, Martina ; Vašicová, Pavla (advisor) ; Kadlečková, Dominika (referee)
Promyelocytic leukemia protein (PML) is a key component for the formation of the PML nuclear bodies (PML−NBs), nonmembrane organelles, in which PML forms a shell surrounding an inner core of this dynamic multiprotein complex. PML is a multifunctional protein that is able to interact with sumoylated proteins and sequestrate them to PML NBs which can work as storage for these proteins or as a platform for biochemical reactions. PML is known for its tumor- suppressive character. However, it can have oncogenic potential under certain conditions which suggests its contradictory role in cancer. PML NBs are highly dynamic structures that undergo structural changes due to the phase of the cell cycle which can physically interact with chromatin. PML NBs maintain genome stability by playing a role during important cellular processes which are regulation of the cell cycle, DNA repair mechanisms, alternative telomere lengthening in cancer cells, or protection of the genome against viral DNA. PML itself can participate in genome maintenance. Concretely, its cytosolic isoform can have a role in inducing apoptosis. The purpose of this section is to provide information about how PML participates in genome stability maintenance and about the possible consequences of the failure of these mechanisms.
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The role of promyelocytic leukemia protein in genome maintenance
 Kindlová, Martina ; Vašicová, Pavla (advisor) ; Moudrý, Pavel (referee)
Promyelocytic leukemia protein (PML) is a key component for a formation of the PML nuclear bodies (PML−NBs) in which PML forms a shell surrounding an inner core of this dynamic multiprotein komplex. PML may act as a tumor supressor or a regulator of transcription factors. PML-NBs plays a role in the genome stability maintenance by participating in DNA repair including the alternative lenghtening of telomer, regulation of the cell cycle and antivirus protection. The purpose of this section is to provide information about how PML participate in the genome stability maintenance and about possible consequences of failure of these mechanisms.
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